S1P d20:1, an endogenous modulator of S1P d18:1/S1P2‐dependent signaling
نویسندگان
چکیده
منابع مشابه
S1P signaling: new therapies and opportunities
Development of sphingosine-1-phosphate receptor 1 (S1P1) modulators to dampen inflammation and its sequelae is becoming increasingly promising for treating medical conditions characterized by significant immunopathology. As shown by the non-selective S1P receptor modulator FTY720 (fingolimod [Gilenya(®)]) in the treatment of relapsing-remitting multiple sclerosis (MS), the ability to use S1P1 m...
متن کاملExogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling.
Initial and recurrent stroke produces central nervous system (CNS) damage, involving neuroinflammation. Receptor-mediated S1P signaling can influence neuroinflammation and has been implicated in cerebral ischemia through effects on the immune system. However, S1P-mediated events also occur within the brain itself where its roles during stroke have been less well studied. Here we investigated th...
متن کاملWhen S1P meets ATP
Biological cells possess plenty of mechanisms to maintain intracellular cell volume if they are challenged by changes of osmolarity. For example, if the extracellular space becomes hypoosmolar or the intracellular osmolarity increases due to a massive influx of NaC ions, the accompanying water influx leads to cell swelling. The cells compensate for this by extrusion of water together with intra...
متن کاملS1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling
Sphingosine-1-phosphate (S1P) is a potent lipid signaling molecule that regulates pleiotropic biological functions including cell migration, survival, angiogenesis, immune cell trafficking, inflammation, and carcinogenesis. It acts as a ligand for a family of cell surface receptors. S1P concentrations are high in blood and lymph but low in tissues, especially the thymus and lymphoid organs. S1P...
متن کاملThymic egress: S1P of 1000
Recent studies have begun to illuminate the mechanism of T-cell export from the thymus, with the identification of a required lysophospholipid receptor, two upstream transcription factors, and several downstream regulators of cytoskeleton dynamics. This work has generated immediate translational impact, aiding the design of immunosuppressant drugs and the identification of a novel form of human...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2020
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.201902391r